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Berman, E, Gee TS, Kempin SJ, Gulati S, Andreeff M , Gabrilove J, Kolitz J, Reich L, Mayer K, Miller W, Raymond G, Young CW, Clarkson BD

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During brain activation, consistent with low O 2 , an increase in lactate in the extracellular space will enhance vasodilation by assisting in the accumulation of prostaglandin E2 (PGE2)